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This relationship supports the hypothesis that much of tirzepatide's anti-inflammatory benefit may be mediated through weight loss rather than direct receptor-mediated anti-inflammatory signaling, though controlled studies specifically addressing this question are limited

Skin Biopsy Skin biopsies were obtained at baseline and after 28 d from the proximal thigh (20 cm below the anterior superior iliac spine) and the distal leg (10 cm above the lateral malleolus) by using a disposable punch biopsy (3 mm) and processed following established guidelines (25)

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